New Orleans Plantation, Mississippi River Cruise

American Cruise Lines - Mississippi River Cruises


Cruise the legendary Mississippi River and take a journey through history with American Cruise Lines. The Mighty Mississippi is navigable from New Orleans, Louisiana, to the Twin Cities of Minnesota. Along the way, follow in the footsteps of the pioneers who first traveled these world-famous waters.

Exclusive $100 Per Stateroom Onboard Credit only from Pleasant Holidays
  • For new bookings made through 12/31/24, for travel anytime.
American Harmony Cruise

Lower Mississippi River Cruise

Delve into the history of the Civil War on this unforgettable cruise along the Lower Mississippi aboard the American Harmony (maximum capacity: 190 guests)

Mississippi River Cruise

Highlights of Mississippi River Cruise

5-Day sojourn through the Mississippi River featuring exquisite Cajun and Creole cuisine.

Mississippi River Gateway Cruise

Mississippi River Gateway Cruise

11-Day journey from New Orleans to St. Louis featuring delectable cuisine, stunning scenery, and fascinating historic landmarks.

Mississippi River Gateway Cruise

Complete Mississippi River Cruise

While cruising Lower Mississippi, explore fascinating ports, antebellum plantations, and Civil War battlefields led by our local expert guides. As you journey up the river, discover a land of sprawling nature preserves and vivid American towns that bring you back to an earlier time.  

One-stop shopping - Book complete cruise vacations with flights, transfers,
pre- and post-cruise stays, onboard accommodations, activities and more
For Cruise Dates, More Itineraries and Bookings
Call Our Dedicated Cruise Desk at

Exclusive Onboard Credit Offer: Onboard credit (OBC) is $100 per stateroom based on double occupancy for new bookings for travel anytime in 2024. The onboard credit is exclusive to American Cruise Lines bookings made through Pleasant Holidays.
Not responsible for errors or omissions. [Pleasant Holidays acts only as an agent for the various travel providers shown above.]